Human Complex Genetics

This course provides an introduction into the field of complex genetics. Also referred to as population genetics; generating large-scale genetic datasets and then answering relevant biological or clinical questions. The course is split in four contact days and and exam:

Day 1: Introduction to complex genetics and genome-wide association studies (genetic variation, genome-wide association studies - GWAS, applications of complex genetics).

Day 2: Biological interpretation of GWAS results (functional interpretation of genetic variants, gene regulation).

Day 3: Clinical application of GWAS results (disease risk prediction, polygenic risk scores, clinical decision-making).

Day 4: Discussion of assignments; practical examples performed in groups or extracted from literature.

Through these topics the course covers the basics of performing complex genetic studies, as well as some of the most common and currently utilized applications.